Table 3 Bone mass parameters for the mouse limbs as measured by µCT following 1 month on ground or in space

From: Skeletal adaptations in young male mice after 4 weeks aboard the International Space Station

Variables compared

Baseline

Ground

Space

p-value (ground vs. space)

Humerus (Tb.Proximal)

BV/TV (%)

21.23 ± 1.26

13.63 ± 1.49**

14.18 ± 1.92**

0.804

Tb.Th (mm)

0.071 ± 0.002

0.064 ± 0.002*

0.064 ± 0.002*

0.890

Tb.Sp (mm)

0.189 ± 0.006

0.244 ± 0.013*

0.232 ± 0.016*

0.524

Tb.N (mm−1)

2.967 ± 0.123

2.105 ± 0.179**

2.161 ± 0.234**

0.831

Humerus (Ct.Midshaft)

B.Ar/T.Ar (%)

60.31 ± 0.63

61.44 ± 0.64

60.47 ± 0.73

0.543

T.Ar (mm2)

0.957 ± 0.011

0.941 ± 0.022

0.917 ± 0.016

0.545

B.Ar (mm2)

0.577 ± 0.008

0.578 ± 0.016

0.554 ± 0.011

0.431

M.Ar (mm2)

0.380 ± 0.008

0.363 ± 0.010

0.362 ± 0.010

0.989

Ct.Th (mm)

0.187 ± 0.003

0.191 ± 0.004

0.185 ± 0.003

0.444

Femur (Tb.Distal)

BV/TV (%)

29.02 ± 1.05

24.24 ± 1.77*

18.17 ± 0.84***

0.012

Tb.Th (mm)

0.057 ± 0.002

0.054 ± 0.002

0.048 ± 0.002*

0.113

Tb.Sp (mm)

0.125 ± 0.001

0.144 ± 0.004**

0.154 ± 0.003***

0.030

Tb.N (mm−1)

7.069 ± 0.041

6.352 ± 0.084***

6.039 ± 0.099***

0.016

Femur (Ct.Midshaft)

B.Ar/T.Ar (%)

46.52 ± 1.67

45.73 ± 0.859

44.53 ± 0.786

0.734

T.Ar (mm2)

2.074 ± 0.078

2.138 ± 0.135

2.077 ± 0.062

0.957

B.Ar (mm2)

0.962 ± 0.034

0.973 ± 0.046

0.924 ± 0.018

0.700

M.Ar (mm2)

1.112 ± 0.068

1.164 ± 0.090

1.154 ± 0.048

0.940

Ct.Th (mm)

0.218 ± 0.008

0.216 ± 0.003

0.207 ± 0.003

0.442

Tibia (Tb.Proximal)

BV/TV (%)

25.07 ± 0.78

25.11 ± 1.91

18.18 ± 0.69**

0.006

Tb.Th (mm)

0.052 ± 0.001

0.052 ± 0.001

0.045 ± 0.003*

0.056

Tb.Sp (mm)

0.126 ± 0.002

0.130 ± 0.005

0.154 ± 0.007**

0.015

Tb.N (mm−1)

7.070 ± 0.113

6.897 ± 0.200

5.965 ± 0.353*

0.038

Tibia (Ct.Midshaft)

B.Ar/T.Ar (%)

69.30 ± 0.81

70.67 ± 1.11

69.59 ± 1.67

0.835

T.Ar (mm2)

1.056 ± 0.022

1.034 ± 0.046

1.025 ± 0.034

0.979

B.Ar (mm2)

0.732 ± 0.018

0.731 ± 0.036

0.715 ± 0.039

0.912

M.Ar (mm2)

0.324 ± 0.010

0.303 ± 0.017

0.310 ± 0.011

0.715

Ct.Th (mm)

0.259 ± 0.005

0.263 ± 0.009

0.257 ± 0.013

0.961

  1. Values are expressed as mean ± S.E.M.
  2. p-values calculated using one-way ANOVAs followed by Holm–Sidak post-hoc analyses. Bolded values to highlight significant p-values
  3. Humeri: n = 10. Femora and tibiae: n = 5. BV bone volume, TV tissue volume, Tb.Th trabecular thickness, Tb.Sp trabecular spacing, Tb.N trabecular number, B.Ar bone area, T.Ar tissue area, M.Ar marrow area, Ct.Th cortical thickness
  4. For comparisons to baseline: *p < 0.05, **p < 0.01, ***p < 0.001
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