Table 2 Detectability of SANS signs by diagnostic device/test.

SANS sign

OCT

Fundus

MRI

US

VF

Optic disc edema

+++

++

Very low sensitivity

–

Indirect indication (if enlarged blind spot or scotoma detected)

Retinal nerve fiber thickening

+++

–

–

–

–

Chorioretinal folds and peripapillary wrinkles

+++

Low-to- moderate sensitivity

–

–

–

Cotton wool spots

High sensitivity (with MultiColor Imaging)

High sensitivity and specificity

–

–

–

Retinal hemorrhages

NA

–

–

–

Globe flattening

–

–

High sensitivity

Low-to- moderate sensitivity

Indirect indication

Refractive error shift

–

–

Indirect indication

High sensitivity

–