Table 1 Summary of the response of each genotype to isolation, simulated microgravity, or both.

Genotype	Treatment	Hippocampus	Plasma
Wild type	Isolation	Upregulation of 11 cytokines (IL-6, IFN-γ, IL-4, IL-9, IL-13, LIF, MCP-1, M-CSF, TNF-α, MIG, G-CSF); Fig. 2	Upregulation of two cytokines (Eotaxin, MDC); Fig. 7
Wild type	Isolation		Downregulation of corticosterone levels^a
MCAT	Isolation	Mitigation of cytokine changes; Fig. 2	No mitigation of cytokine changes; Fig. 7
MCAT	Isolation	Mitigation of cytokine changes; Fig. 2	No change in corticosterone levels
Wild type	Simulated microgravity	Upregulation of four (IL-3, IL-1β, IL-10, IL-17) and downregulation of one cytokine(s) (IL-12); Fig. 4	Upregulation of one cytokine (IL−20); Fig. 6
Wild type	Simulated microgravity		Upregulation of corticosterone levels
MCAT	Simulated microgravity	Mitigation of cytokine changes; Fig. 4	Mitigation of cytokine changes; Fig. 6
MCAT	Simulated microgravity	Mitigation of cytokine changes; Fig. 4	Mitigation of corticosterone changes
Wild type	Isolation + Simulated microgravity	Downregulation of one cytokine (IL-13); Fig. 3	Upregulation of two (IL−20, IFN-β1) and downregulation of one cytokine(s) (MDC); Fig. 5
Wild type	Isolation + Simulated microgravity	Downregulation of one cytokine (IL-13); Fig. 3	Upregulation of corticosterone levels
MCAT	Isolation + Simulated microgravity	Mitigation of cytokine change; Fig. 3	Mitigation of cytokine changes; Fig. 5
MCAT	Isolation + Simulated microgravity	Mitigation of cytokine change; Fig. 3	Mitigation of corticosterone changes

The main figure numbers corresponding to the summarized cytokine results are also included in the table. “Mitigation of cytokine change(s)” (by MCAT) pertains to mitigation of all the cytokine changes observed in the corresponding wild-type group.
^aOnly in NL groups; Corticosterone levels in HU groups are not further reduced by isolation.

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