Fig. 4: Workflow proposal.

In order to minimize the damage of long-term spaceflights and missions to Mars and beyond, it is of great importance to assess the health state and endogenous capacity of astronauts and future space travelers to resist ROS damage. This information will help to stratify the health and endogenous capacity of astronauts to resist environmental and psychological stress of future crew members and provide personalized antioxidant cocktails to prevent ROS and other forms of damage. Monitoring inflight ROS levels, cellular damage, and stress could help to apply preventive or protective strategies specially when astronauts could be exposed to high levels of ionizing radiation such as those experienced during deep-space missions. Continuous monitoring of health during space travel will help to prevent health problems and improve the security of space exploration. Created with BioRender.com.