Table 1 Proposed antioxidants cocktail19,127,208,212,215,216,217,218,219,220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239,240,241,242,243,244,245,246,247,248,249,250,251,252,253,254,255,256,257,258,259,260,261,262,263.

From: Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions

Stratification of astronauts and space travelers accordingly to the exogenous and endogenous antioxidant levels (GWAS, Nutrigenomics Vit C, and GSH assessment)

Low antioxidant protective levels

Intermediate levels

High antioxidant levels, male/female

Vitamin/antioxidant doses based on the astronaut

2 doses per day: 1 every 12 h

1 dose per day

1 dose per day

 Vitamin A

1000 mg

50 mg/day

900/700 µg

 Vitamin C

4–8 g

1–2 g

90/75–200 mg

 Vitamin E

800 to 1200 mg

60–800 mg

15 mg

 Vitamin D

50 µg

15–20 µg

15–20 µg

 Selenium as L-SeMeT

400 µg

200 µg

55 µg

 Resveratrol

1000–1500 mg

500 mg

10 mg

 Isorhamnetin

100 mg/kg

100 mg/kg

20–50 mg/kg

 Luteolin

100 mg/kg

50 mg/kg

50 mg/kg

 CoQ10

1200 mg

20/mg/kg

12/mg/kg