Table 3 Summary of significantly altered gene expressions by spaceflight related to neuronal support cell function.
From: Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission
Gene | p value | Log2 fold Δ | Related molecule function |
|---|---|---|---|
CSF1R | 0.0111 | −0.209 | Cell-surface receptor regulating development, proliferation and differentiation. |
PLP1 | 0.00283 | −0.363 | Major myelin protein in the CNS. |
MERTK | 0.000256 | −0.368 | Signaling protein in innate immune cells mediating engulfment of apoptotic cells. |
TREM2 | 0.0359 | −0.461 | Regulates microglial chemotaxis and phagocytosis of apoptotic neurons. |
NCF1 | 0.0214 | −0.539 | Subunit of NADPH oxidase required for superoxidase production. |
OPALIN | 0.0205 | −0.546 | Regulator of oligodendrocyte cytoskeletal remolding and morphology. |
SLC2A5 | 0.0132 | −0.623 | Fructose transporter found in microglial cells. |
