Table 3 Gene ontology analysis by strain in simulated microgravity compared to control.

From: Genetic diversity modulates the physical and transcriptomic response of skeletal muscle to simulated microgravity in male mice

Strain

Upregulated gene ontology biological process

P-value

FDR

Downregulated gene ontology biological process

P-value

FDR

All

DNA Metabolic Process

4.6e−05

0.048

Negative regulation of angiogenesis

7.9e−06

0.012

 

Sarcomere organization

0.0001

0.049

Response to unfolded protein

9.7e−06

0.012

 

Striated muscle contraction

0.00013

0.049

Telomere maintenance via telomerase

0.00011

0.027

WSB/EiJ

   

Response to unfolded protein

6e−09

1.3e−05

    

‘de novo’ posttranslational protein folding

5.2e−07

0.00056

    

Chaperone mediated protein folding requirement cofactor

1.4e−06

0.001

PWK/PhJ

Cotranslational protein targeting to membrane

3.2e−32

7.3e−29

Actin-myosin filament sliding

3.e−07

0.00029

 

Protein targeting to ER

4.3e−30

3.2e−27

Striated muscle contraction

2.5e−06

0.0013

 

rRNA metabolic process

6.1e−18

1.3e−15

Glycogen catabolic process

3.4e−06

0.0013

NZO/HILtJ

Striated muscle contraction

1.9e−11

2.8e−08

Negative regulation of cellular process

2.5e−08

6.3e−05

 

Actin-myosin filament sliding

1.4e−09

5.2e−07

Extracellular matrix organization

1.4e−06

0.0017

 

Sarcomere organization

4.4e−08

1.4e−05

Regulation of angiogenesis

1e−05

0.0062

NOD/ShiLtJ

   

Negative regulation of transcription, DNA-templated

1.7e−05

0.02

    

Myelination

3.1e−05

0.024

    

Negative regulation of transcription from RNA polymerase II promoter

9.6e−05

0.046

129S1/SvImJ

   

Positive regulation of cell differentiation

1.2e−10

3.1e−07

    

Cellular amino acid catabolic process

2.1e−09

2.8e−06

    

Regulation of cell migration

1.5e−06

0.0005

CAST/EiJ

Muscle contraction

3e−11

4.8e−08

Extracellular matrix organization

4.4e−12

8.9e−09

 

Actin-myosin filament sliding

7.8e−11

4.8−08

Peptide metabolic process

3.2e−07

0.00027

 

Myofibril assembly

8.3e−11

4.8e−08

Collagen fibril organization

3.9e−07

0.00027

C57BL/6J

Regulation of transcription from RNA polymerase II promoter

5.5e−10

1.3e−06

Respiratory chain complex IV assembly

2.8e−05

0.022

 

RNA 3’ end processing

2.5e−06

0.0018

mRNA processing

3.2e−05

0.022

 

Termination of RNA polymerase II transcription

4.7e−05

0.016

Polyamine biosynthetic process

0.00029

0.074

A/J

SRP-dependent Cotranslational protein targeting to membrane

5.8e−13

1.1e−09

Cellular response to cytokine stimulus

6.1e−24

1e−20

 

Peptide biosynthetic process

8e−08

2.2e−05

Cytokine-mediated signaling pathway

7.4e24

1e−20

 

Translation

1.7e−06

0.00032

Positive regulation of transcription from RNA polymerase II promoter

3.5e−12

2.5e−09

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