Table 1 Research question in PICOS Format.

From: Systematic review of the use of ultrasound for venous assessment and venous thrombosis screening in spaceflight

PICOS items

Search type

Participants

Human participants during spaceflights

Interventions

Spaceflight venous ultrasound (short-term or long-term spaceflights, or acute exposure to microgravity)

Comparison

Terrestrial venous ultrasound

Outcomes

Venous ultrasound morphological and physiological changes during spaceflights

Effect of inflight countermeasures/ interventions on venous ultrasound changes

Gaps and technical issues when performing spaceflight venous ultrasound (i.e., appropriateness of spaceflight venous ultrasound)

Study design

Observational (descriptive or comparative) and interventional studies

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