Table 4 Summary of analysis of tissue oxygenation measurements (%) captured by near-infrared spectroscopy device at the temporal region, venous angles, and forehead
Timepoint | Temporal lobe, frontal | Venous angle, frontal | Venous angle, lateral | Forehead | |||
|---|---|---|---|---|---|---|---|
Left, n = 12 | Right, n = 12 | Left, n = 13 | Right, n = 12 | Left, n = 12 | Right, n = 13 | n = 13 | |
Baseline | |||||||
Median, % Interquartile range Marginal mean (SE) | 75 73–80 76.7 (1.4) | 74 72–78 74.5 (1.1) | 72 64–75 70 (2.1) | 69 61–74 67.1 (2.8) | 77 74–80 75.8 (1.8) | 74 67–78 72.9 (2.2) | 77 74–78 75.1 (1.6) |
Post-30 min | |||||||
Median, % Interquartile range Marginal mean (SE), % Mean % change from baseline 90% confidence interval P value | 72 71–77 73 (1.4) −3.67 −6.04 to −1.29 0.011 | 73 69–76 72.7 (1.4) −1.78 −3.18 to −0.38 0.036 | 65 61–70 65.1 (1.7) −4.83 −7.18 to −2.47 0.001 | 65 62–68 63.6 (2.2) −3.46 −6.26 to −0.66 0.042 | 72 63–76 70.9 (1.9) −4.96 7.30 to −2.62 0.001 | 69 63–75 69 (2.2) −3.90 −5.61 to −2.19 <0.001 | 75 69–76 73.1 (1.2) −1.99 −4.07–0.09 0.116 |
Post-60 min | |||||||
Median, % Interquartile range Marginal mean (SE), % Mean % change from baseline 90% confidence interval P value | 72 71–73 72 (0.9) −4.67 −6.77 to −2.50 <0.001 | 71 70–76 71.9 (1.2) −2.55 −4.48 to −0.62 0.030 | 65 57–66 63.1 (2.1) −6.86 −9.16 to −4.57 <0.001 | 61 58–66 60.2 (2.2) −6.84 −9.99 to −3.68 <0.001 | 70 67–75 69.6 (1.7) −6.20 −8.35 to −4.05 <0.001 | 69 63–74 67.9 (2.3) −4.99 −7.39 to −2.58 0.001 | 72 68–73 70.8 (1.1) −4.34 −6.52 to −2.16 0.001 |
Post-90 min | |||||||
Median, % Interquartile range Marginal mean (SE), % Mean % change from baseline 90% confidence interval P value | 72 70–74 71.3 (0.9) −5.30 −7.61 to −3.00 <0.001 | 71 69–72 71 (1.1) −3.48 −4.75 to −2.21 <0.001 | 61 57–70 63.2 (1.9) −6.79 −8.79 to −4.79 <0.001 | 60 57–70 61 (3) −6.04 −8.50 to −3.58 <0.001 | 71 64–75 69.9 (2.1) −5.92 −8.57 to −3.28 <0.001 | 66 61–72 67.3 (2.1) −5.58 −7.99 to −3.17 <0.001 | 71 67–73 69.9 (1.1) −5.20 −7.32 to −3.07 <0.001 |
Post-120 min | |||||||
Median, % Interquartile range Marginal mean (SE), % Mean % change from baseline 90% confidence interval P value | 72 70–73 71.6 (0.7) −5.09 −7.30 to −2.89 <0.001 | 71 68–72 70.7 (1) −3.84 −5.71 to −1.96 0.001 | 67 63–71 66.2 (1.7) −3.79 −5.93 to −1.66 0.003 | 64 60–68 62.8 (2.5) −4.31 −6.25 to −2.36 <0.001 | 72 71–76 71.9 (1.6) −3.88 −6.18 to −1.57 0.006 | 70 65–74 67.9 (2.3) −4.98 −8.01 to −1.96 0.007 | 70 66–73 69.9 (1.3) −5.27 −7.93 to −2.62 <0.001 |
Post-150 min | |||||||
Median, % Interquartile range Marginal mean (SE), % Mean % change from baseline 90% confidence interval P value | 72 70–74 71.4 (1.0) −5.26 −6.86 to −3.67 <0.001 | 71 68–72 70.2 (1.1) −4.27 −6.46 to −2.07 0.001 | 64 59–70 64 (2.2) −6.02 −8.96 to −3.07 0.001 | 61 57–71 61.1 (3.3) −6.01 −9.45 to −2.57 0.004 | 71 67–74 70.2 (1.6) −5.63 −8.19 to −3.07 <0.001 | 68 64–73 69 (2) −3.81 −6.89 to −0.73 0.042 | 69 66–72 69 (1.5) −6.07 −8.72 to −3.43 <0.001 |
Post-180 min | |||||||
Median, % Interquartile range Marginal mean (SE), % Mean % change from baseline 90% confidence interval P value | 70 66–72 69.1 (0.8) −7.52 −9.94 to −5.10 <0.001 | 68 66–74 69.2 (1.3) −5.29 −7.62 to −296 <0.001 | 58 55–74 62.3 (2.6) −7.65 11.38 to −3.92 0.001 | 60 55–74 58.4 (2.9) −8.63 −11.78 to −5.47 <0.001 | 72 69–76 71.3 (1.5) −4.49 −7.08 to −1.90 0.005 | 70 65–74 68.9 (1.5) −3.97 −7.30 to −0.63 0.051 | 69 65–73 68.7 (1.6) −6.48 −9.26 to −3.69 <0.001 |
Post-195 min (post-MLD) | |||||||
Median, % Interquartile range Marginal mean (SE), % Mean % change from baseline 90% confidence interval P value | 69 68–70 69 (0.6) −7.64 −10.08 to −5.20 <0.001 | 69 67–72 68.7 (0.8) −5.78 −7.86 to −3.70 <0.001 | 63 54–65 60.5 (2.1) −9.46 −12.04 to −6.68 <0.001 | 60 57–66 58.8 (2.8) −8.28 −10.74 to −5.82 <0.001 | 71 66–72 68.5 (1.5) −7.33 −9.90 to −4.77 <0.001 | 67 62–71 66.5 (1.5) −6.32 −8.94 to −3.71 <0.001 | 67 65–72 67.4 (1.2) −7.77 −10.46 to −5.08 <0.001 |
Post-225 min (30 minutes post-MLD) | |||||||
Median, % Interquartile range Marginal mean (SE), % Mean % change from baseline 90% confidence interval P value | 69 67–71 69.1 (0.8) −7.53 −9.25 to −5.81 <0.001 | 69 67–70 68.9 (0.9) −5.62 −7.25 to −4.00 <0.001 | 71 66–74 69.2 (1.6) −0.84 −4.45–2.78 0.703 | 69 66–70 63.4 (1.7) −1.29 −2.34–4.91 0.559 | 66 65–72 67.9 (1.4) −7.90 −10.49 to −5.32 <0.001 | 69 68–72 69 (1.1) −3.84 −6.92 to −0.76 0.040 | 66 64–69 66.3 (1.1) −8.680 −11.07 to −6.54 <0.001 |
