Table 6 Summary of available vitals data and analysis (n = 15)

From: Using noninvasive imaging to assess manual lymphatic drainage on lymphatic/venous responses in a spaceflight analog

Timepoint

Heart rate

Systolic blood pressure

Diastolic blood pressure

Respiratory rate

Body temperature, °C

Blood oxygen levels, %a

Baseline

      

Median (IQR)

Marginal mean (SE)

71.0 (64.0–77.0)

70.5 (2–5)

119.0 (113.0–124.0)

118.8 (2.3)

71.0 (69.0–77.0)

71.9 (1.4)

20.0 (18.0–22.0)

20.4 (0.8)

36.7 (36.6–36.8)

36.7 (0)

98.0 (96.0–99.0)

97.4 (0.5)

Post-30 min

      

Median (IQR)

Marginal mean (SE)

Mean % change from baseline

90% confidence interval

P value

66.0 (60.0–73.0)

66.1 (2.5)

−4.47

−7.55 to –1.38

0.017

117.0 (111.0–123.0)

117.8 (2.3)

−1.00

−5.24–3.24

0.698

75.0 (71.0–78.0)

74.5 (1.4)

2.60

−0.53–5.73

0.172

18.0 (16.0–20.0)

17.7 (0.8)

−2.66

−3.99 to −1.34

0.001

36.7 (36.7–36.8)

36.7 (0)

0.05

−0.02–0.11

0.218

98.0 (96.0–99.0)

97.4 (0.6)

0.000

−0.009–0.010

0.981

Post-60 min

      

Median (IQR)

Marginal mean (SE)

Mean % change from baseline

90% confidence interval

P value

65.0 (59.0–71.0)

65.4 (2.5)

−5.13

−8.22 to −2.05

0.006

116.0 (111.0–118.0)

116.4 (2.3)

−2.40

−6.64–1.84

0.352

75.0 (71.0–77.0)

75.1 (1.4)

3.13

0.00–6.27

0.100

16.0 (14.0–20.0)

16.5 (0.8)

−3.86

−5.19 to −2.54

<0.001

36.7 (36.6–36.8)

36.7 (0)

−0.01

−0.07–0.06

0.850

98.0 (98.0–99.0)

97.7 (0.5)

0.003

−0.005–0.011

0.519

Post-90 min

      

Median (IQR)

Marginal mean (SE)

Mean % change from baseline

90% confidence interval

P value

63.0 (58.0–67.0)

63.7 (2.5)

−6.87

−9.95 to −3.78

<0.001

121.0 (119.0–126.0)

122.7 (2.3)

3.87

−0.37–8.10

0.133

78.0 (71.0–80.0)

75.5 (1.4)

3.60

0.47–6.73

0.059

16.0 (14.0–18.0)

15.9 (0.8)

−4.53

−5.86 to −3.21

<0.001

36.6 (36.6–36.9)

36.7 (0)

0.02

−0.05–0.08

0.636

99.0 (97.0–99.0)

97.4 (0.6)

0.000

−0.006–0.006

0.943

Post-120 min

      

Median (IQR)

Marginal mean (SE)

Mean % change from baseline

90% confidence interval

P value

63.0 (57.0–74.0)

64.4 (2.5)

−6.13

−9.22 to −3.05

0.001

118.0 (111.0–128.0)

121.7 (2.3)

2.93

−1.30–7.17

0.255

76.0 (73.0–83.0)

78.3 (1.4)

6.33

3.20–9.47

0.001

16.0 (14.0–18.0)

16.7 (0.8)

−3.73

−5.06 to −2.41

<0.001

36.6 (36.6–36.7)

36.6 (0)

−0.07

−0.14 to −0.01

0.058

98.0 (97.0–99.0)

97.4 (0.6)

0.000

−0.009–0.010

0.955

Post-150 min

      

Median (IQR)

Marginal mean (SE)

Mean % change from baseline

90% confidence interval

P value

63.0 (56.0–75.0)

63.6 (2.5)

−6.93

−10.02 to −3.85

<0.001

121.0 (114.0–127.0)

120.0 (2.3)

1.20

−3.04–5.44

0.641

79.0 (75.0–81.0)

78.1 (1.4)

6.13

3.00–9.27

0.001

16.0 (14.0–16.0)

15.6 (0.8)

−4.80

−6.13 to −3.47

<0.001

36.6 (36.5–36.7)

36.5 (0)

−0.13

−0.19 to −0.07

0.001

99.0 (98.0–99.0)

98 (0.4)

0.006

−0.002–0.013

0.224

Post-180 min

      

Median (IQR)

Marginal mean (SE)

Mean % change from baseline

90% confidence interval

P value

58.5 (54.0–71.0)

62.6 (2.5)

−7.90

−11.04 to −4.75

<0.001

122.0 (115.0–122.0)

122.4 (2.3)

3.62

−0.70–7.94

0.168

76.0 (73.0–80.0)

76 (1.4)

4.08

0.89–7.27

0.036

16.0 (14.0–18.0)

15.8 (0.8)

−4.56

−5.91 to −3.21

<0.001

36.6 (36.6–36.6)

36.6 (0)

−0.12

−0.18 to −0.05

0.003

99.0 (98.0–99.0)

98.2 (0.4)

0.008

−0.001–0.017

0.122

Post-195 min (Post-MLD)

      

Median (IQR)

Marginal mean (SE)

Mean % change from baseline

90% confidence interval

P value

67.0 (60.0–77.0)

66.7 (2.5)

−3.80

−6.88 to −0.72

0.043

119.0 (116.0–127.0)

121.8 (2.3)

3.00

−1.24–7.24

0.244

82.0 (77.0–87.0)

81.4 (1.4)

9.47

6.33–12.60

<0.001

16.0 (16.0–18.0)

16.4 (0.8)

−4.00

−5.33 to −2.67

<0.001

36.6 (36.5–36.6)

36.6 (0)

−0.11

−0.18 to −0.05

0.003

99.0 (98.0–99.0)

98 (0.4)

0.006

−0.001–0.012

0.178

Post-225 min (30 minutes–Post-MLD)

      

Median (IQR)

Marginal mean (SE)

Mean % change from baseline

90% confidence interval

P value

60.0 (56.0–75.0)

66.7 (2.5)

−7.20

−10.26 to −4.14

0.000

123.0 (119.0–132.0)

125.4 (2.3)

6.60

2.52–10.68

0.008

80.0 (76.0–85.0)

80.3 (1.4)

8.33

5.21–11.45

0.000

16.0 (14.0–18.0)

15.3 (0.8)

−5.07

−6.41 to −3.72

0.000

36.6 (36.5–36.7)

36.6 (0)

−10.

−0.16 to −0.03

0.010

99.0 (98.0–99.0)

98.2 (0.3)

0.01

−0.00–0.02

0.111

  1. IQR interquartile range, MLD manual lymphatic drainage, SE standard error.
  2. aMeasured using pulse oximeter.
  3. The final timepoint [post-225 min (30-minutes post-MLD)] was assessed in the sitting position, while all prior timepoints were assessed in the head-down tilt position.
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