Table 1 Spaceflight-exposed kidney shows cholesterol and protein synthesis pathways up and downregulated, respectively, in both lineages, while extracellular matrix pathways show downregulation in C57BL/6J and upregulation in BALB/c mice

From: Spaceflight causes strain-dependent gene expression changes in the kidneys of mice

 

Upregulated in C57BL/6J

Downregulated in C57BL/6J

BALB/c

up

Cholesterol Biosynthesis Pathway

Cholesterol biosynthetic

Cholesterol biosynthesis

Superpathway of cholesterol biosynthesis

Cholesterol Biosynthesis with Skeletal Dysplasias

Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways)

Steroid biosynthetic

Regulation of cholesterol biosynthesis by SREBP (SREBF)

Cholesterol biosynthesis, squalene 2,3-epoxide → cholesterol

Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)

Genes encoding secreted soluble factors

Ensemble of genes encoding ECM-associated proteins, including ECM-affiliated proteins, ECM regulators and secreted factors

Kisspeptin/Kisspeptin Receptor System in the Ovary

E3 ubiquitin ligases ubiquitinate target proteins

Ovarian steroidogenesis

Protein ubiquitination

Ensemble genes encoding extracellular matrix and extracellular matrix-associated proteins

TGF-beta signalling pathway

BALB/c down

N/A

Peptide chain elongation

Eukaryotic Translation Elongation metabolism

Ribosome

Cytoplasmic Ribosomal Proteins

Viral mRNA Translation

Selenocysteine synthesis

Translation

Eukaryotic Translation Termination

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

  1. Biological process pathways enriched by overrepresentation of differentially expressed genes in kidney transcriptomic data from C57BL/6J (RR-1) and BALB/c (RR-3) mice (FDR < 0.05).