Table 1 Spaceflight-exposed kidney shows cholesterol and protein synthesis pathways up and downregulated, respectively, in both lineages, while extracellular matrix pathways show downregulation in C57BL/6J and upregulation in BALB/c mice
From: Spaceflight causes strain-dependent gene expression changes in the kidneys of mice
Upregulated in C57BL/6J | Downregulated in C57BL/6J | |
---|---|---|
BALB/c up | Cholesterol Biosynthesis Pathway Cholesterol biosynthetic Cholesterol biosynthesis Superpathway of cholesterol biosynthesis Cholesterol Biosynthesis with Skeletal Dysplasias Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways) Steroid biosynthetic Regulation of cholesterol biosynthesis by SREBP (SREBF) Cholesterol biosynthesis, squalene 2,3-epoxide → cholesterol Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) | Genes encoding secreted soluble factors Ensemble of genes encoding ECM-associated proteins, including ECM-affiliated proteins, ECM regulators and secreted factors Kisspeptin/Kisspeptin Receptor System in the Ovary E3 ubiquitin ligases ubiquitinate target proteins Ovarian steroidogenesis Protein ubiquitination Ensemble genes encoding extracellular matrix and extracellular matrix-associated proteins TGF-beta signalling pathway |
BALB/c down | N/A | Peptide chain elongation Eukaryotic Translation Elongation metabolism Ribosome Cytoplasmic Ribosomal Proteins Viral mRNA Translation Selenocysteine synthesis Translation Eukaryotic Translation Termination Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |