Fig. 2: Identification of radiation-related key molecular networks. | npj Microgravity

Fig. 2: Identification of radiation-related key molecular networks.

From: Exploring molecular and modular insights into space ionizing radiation effects through heterogeneous gene regulatory networks

Fig. 2

A Heatmap of differentially expressed genes in human lymphocytes after 2 Gy γ-irradiation (|log2FC | >1, adjusted p < 0.05; rows: genes, columns: samples). Color represents row-scaled mean expression value (red: upregulation; blue: downregulation). B Heatmap of differentially expressed miRNAs (|log2FC | >1, p < 0.05; rows: genes, columns: samples). Color represents the same criteria as (A). C Radiation-related key molecule network derived from comprehensive heterogeneous gene regulatory network incorporating deferentially-expressed genes and miRNAs. The triangle, diamond and circular nodes represent miRNA, TF and gene, respectively. Pink and blue represent seed nodes and non-seed nodes, respectively. The size of the node represents the levels of the node degree.

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