Fig. 2: In vitro treatment of primary osteocytes with high concentrations of TGFβ1. | npj Microgravity

Fig. 2: In vitro treatment of primary osteocytes with high concentrations of TGFβ1.

From: BMP9 attenuates microgravity-related disuse osteoporosis by modulating TGFβ and BMP signaling

Fig. 2

A Western blot analysis of phosphorylated Smads in primary osteocytes stimulated with a high dose of TGFβ1 for 3 days. B Expression of BMP-pSmad1/5/8 downstream target genes in primary osteocytes treated with varying concentrations of TGFβ1 for 3 days. C Intracellular pH changes in response to different concentrations of TGFβ1. D Expression of osteolytic factors in primary osteocytes induced by different concentrations of TGFβ1. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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