Fig. 5: Effect of PEFs on calcium signaling. | npj Flexible Electronics

Fig. 5: Effect of PEFs on calcium signaling.

From: Integrating flexible electronics for pulsed electric field delivery in a vascularized 3D glioblastoma model

Fig. 5

a Picture from the top of the device placed on a U87-GCaMP6f spheroid grafted in the CAM observed at λexc = 490 nm and a zoom on the region of interest. The fluorescence is measured on the ROI depicted in yellow. Scale bars are respectively 400 µm and 100 µm. b Normalized fluorescence intensity measured over time depending on the voltage applied. c Dose–response: maximum fluorescence change depending on the voltage applied: 0 V (n = 7), 5 V (n = 5), 10 V (n = 4), 15 V (n = 5), 20 V (n = 3), 25 V (n = 3), 30 V (n = 2). Error bars indicate standard deviations.

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