Fig. 7: Design history of the TIME implants. | npj Flexible Electronics

Fig. 7: Design history of the TIME implants.

From: Bringing sensation to prosthetic hands—chronic assessment of implanted thin-film electrodes in humans

Fig. 7

TIME-2 was mostly used in small animal experiments, proving biocompatibility of the used materials29 and showing advantages in the stimulation selectivity19. TIME-3 implants were used mainly in large nerves of pigs30,31. SIROF was applied as contact material to increase the charge injection capacity and thus increase the stimulation safety limits14,45. In a first-in-human study the TIME-3H showed excellent clinical outcomes1,32, but as well weak points concerning the mechanical integrity, especially of the ground contact sites33. SiC was introduced as adhesion promoting layer and the large area ground contact site was split into 109 redundant connected small contact sites.

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