Fig. 5: Polymer Surface Modification.60.
From: Long-term stability strategies of deep brain flexible neural interface
a Neural Fringe Electrode (i) Neural fringe/PEG assembly; (ii) Immunohistochemical staining and bright-field image of horizontal brain slices 5 weeks post-implantation; b Bilayer Silk-Parylene Electrode61. (i) SEM image of the bilayer silk-parylene shank; (ii) Enlarged SEM image of (i); (iii) Schematic of the bilayer silk-parylene electrode with feature dimensions; (iv) Enzymatic degradation of silk in the bilayer silk-parylene probe; c 3D Nanomesh Electrode66. (i) Shape of the 3D nanomesh electrode; (ii) 3D reconstructed confocal micrograph projection of cross-sectional slices immunochemically labeled 5 weeks post-implantation. Blue: nuclei (Hoechst); Green: NeuN (neuronal nuclei); White: SU-8; Red: GFAP (reactive astrocytes). The right panel shows the fluorescence intensity distribution of astrocytes (red channel) along the long axes of the two dashed box regions; d Liquid Metal Electrode67. (i) Diagram of the liquid metal electrode and its filling pressure; (ii) Liquid metal electrode in rigid state and integrated drug delivery state (The scanning electron microscope image of the electrode tip in the box shows the drug delivery channel). Reproduced under terms of the CC-BY license60. Copyright 2019, Shouliang, G., Jinfen, W., Xiaowei, G., et al., published by Science Advances. Reproduced with permission61. Copyright 2022, Clement, C., Adrian, L., Lionel G., N., et al. Reproduced with permission66. Copyright 2015, Chong, X., Jia, L., Tian-Ming, F., et al., published by Springer Nature. Reproduced with permission67. Copyright 2019, Elsevier B.V.
