Table 2 Meta-analytical evidence for biomarker specificity of regional atrophy in CBS/CBD as measured with MRI
Disease | Study | Anatomical region | ||||
|---|---|---|---|---|---|---|
| Â | Â | Thalamus | Bl. fronto-median and midcingulate cortex | Bl. premotor area and supplementary motor area | L. pre-central gyrus | L. superior frontal sulcus and middle frontal gyrus |
Parkinson’s syndromes | ||||||
 Parkinson’s disease | − | − | − | + | + | |
 Atypical Parkinson’s syndromes | ||||||
   CBD and syndrome | Present meta-analysis | + | + (posterior) | + | + | + |
   Progressive supranuclear palsy | + | − | − | + | − | |
   Multiple system atrophy | + | − | − | − | − | |
   Lewy body dementia | 40* | (−) | (−) | (−) | (−) | (−) |
Alzheimer’s disease | + | − | − | − | − | |
Behavioral variant frontotemporal dementia | − | + (anterior) | − | − | − | |
Primary progressive aphasias | ||||||
 Nonfluent/ agrammatic variant (progressive non-fluent aphasia) | − | − | − | − | + | |
 Semantic variant (semantic dementia) | − | − | − | − | − | |
 Logopenic variant (logopenic aphasia) | − | − | − | − | − | |
