Fig. 2
From: Embryonic development of selectively vulnerable neurons in Parkinson’s disease
Hypothesis: neurons selectively vulnerable to degeneration in PD share similarities in their cellular and molecular developmental programs. Vulnerable neuronal populations share certain identifiable phenotypic characteristics. Mature neuronal identity is largely the result of a developmental program, that is specific to each cell type. By comparing and contrasting the cellular developmental lineage and requirement for absence or presence of specific developmental transcription factors, we can discover shared developmental similarities of neurons selectively vulnerable in early PD
