Fig. 3

Regression plot of response inhibition deficits on average disease duration for the “off” medication (blue) and “on” medication (red) samples. Effect sizes less than 0 indicate that PD patients demonstrated poorer response inhibition performance than healthy controls. Each bubble represents a comparison from one study, weighted by within-study variance. Smaller bubbles represent studies with higher variance than others and thus, have less influence on the regression. The regression line of best fit for each sample is also shown. The difference in slopes was significant (z test; p = .04), indicating that “off” medication, deficits were moderate and relatively unaffected by disease duration, whereas “on” medication, deficits were significantly associated by disease duration. *p < .05; ***p = .001