Fig. 4 | npj Parkinson's Disease

Fig. 4

From: Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson’s disease model

Fig. 4

Nanobody treatment induces functional motor recovery. a Results of stepping test behavior to assess unilateral forelimb akinesia induced by synucleinopathy and intrabody treatment effects. Both intrabody-treated cohorts improve use of forelimbs contralateral to site of lesion. b Box-and-whisker graph of study-endpoint stepping test behavioral performance. c Results of cylinder test behavior to assess unilateral forelimb akinesia and intrabody treatment effects. d Box-and-whisker plot of study-endpoint cylinder test behavioral performance. All the data were analyzed via two-way ANOVA with Tukey's post hoc comparisons (saline—n = 14, VH14*PEST—n = 15, NbSyn87*PEST—n = 14, all p values reported are comparisons with control subjects: *p < 0.05, ***p < 0.001, #p < 0.05, or as indicated on the figure. No significant findings were observed in comparison with intrabody-treated cohorts)

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