Fig. 5 | npj Parkinson's Disease

Fig. 5

From: Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson’s disease model

Fig. 5

NbSyn87*PEST treatment elicits inflammatory response in substantia nigra. a Immunolabeling of Iba-1 in the substantia nigra reveals microglial recruitment and activation. NbSyn87*PEST treatment induces higher levels of microglial clustering to the injected substantia nigra than in VH14*PEST-treated animals. NbSyn87*PEST-treated animals also exhibit higher populations of amoeboid microglia indicating active microglial morphology (red arrow, inset) (scale bars: 100 and 25 μm). b Stereological quantification of Iba-1 labeled cells indicates significant increases in microglial recruitment in NbSyn87*PEST, representative of a stronger inflammatory response. Data were analyzed via one-way ANOVA with Tukey's post hoc comparisons (saline—n = 6, VH14*PEST—n = 8, NbSyn87*PEST—n = 7, all *p < 0.05, **p < 0.01)

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