Fig. 2
From: Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice
Behavioral evaluation of VKI mice. a Mice were placed in an open field arena and video recorded as they explored for 15 min. Total distance traveled and moving time was not different across genotypes (i and ii, 1-way ANOVA F2,116 = 0.39, p = 0.67 and F2,116 = 0.71, p = 0.49, respectively). Percentage of central path exploration was also similar across genotypes (iii, 1-way ANOVA F2,116 = 0.06, p = 0.94). b Mice were video recorded for 5 min after being placed in a 1 L-glass beaker. The number of rearings was scored off-line by an experimenter blinded to genotype. Mice show no significant difference in novelty-induced vertical exploration (rearing; 1-way ANOVA F2,109 = 0.33 p = 0.71). c Mice were placed on an accelerating rotarod (from 4 to 36 RPM) for 5 min. A fall or hold on the rotarod for a revolution was considered a fail event. VKI mice show no differences in their performance when compared with their WT littermates (i and ii, fail per acceleration: 2-way ANOVA interaction F18,882 = 1.73, p = 0.03, RPM F9,882 = 104.9, p < 0.0001, genotype F2,98 = 1.28, p = 0.28, subjects F98,882 = 2.58, p < 0.0001, and total fails during testing: 1-way ANOVA F2,100 = 1.45, p = 0.24, respectively)
