Fig. 3 | npj Parkinson's Disease

Fig. 3

From: Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation

Fig. 3

Anti-E1 immunotherapy in WEEV-infected CD-1 mice rescues from lethal infection and facilitates clearance of virus by 8 weeks post infection. a, b Mice were infected with McFly and received either a mock treatment (naive pre-immune serum) or anti-E1 immunotherapy (anti-E1 polyclonal rabbit immune serum). Bioluminescence measurements were acquired every 24 h following inoculation. c Immunotherapy treatment was optimized to achieve consistent CNS infection without mortality, demarcated by red lines indicating the upper and lower range of acceptable luciferase activity. For each treatment regimen, the measured luciferase activity is shown for the head region. Volumes indicate amount of immunized rabbit serum administered. 2X means the animals in that group received doses of immune serum at both 12 and 48 h post infection. d Survival curves for the different treatment regimens employed. e, f Following treatment with immune serum at 12 and 48 h post infection, regimen after intranasal infection with McFly and McRed, animals completely cleared virus by 8 weeks post infection

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