Fig. 1: Timing variability correlated with cognitive dysfunction in Parkinson’s disease (PD).
From: Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson’s disease
a PD patients with a range of cognitive function and demographically matched controls performed an interval-timing task at one of two intervals: 3 s or 7 s. This task required participants to press the spacebar (termed “keypress”) when they estimated the target interval to have elapsed. b Density estimates of keypress over time during 3-s intervals. Of recruited participants, only 31 controls and 52 PD patients had enough trials to analyze for 3-s intervals. c Density estimates of keypress over time for 7-s intervals from controls (n = 37) and PD (n = 71) patients. Mean response times for d 3-s and e 7-s intervals for control (blue) and PD patients (red). Timing variability as measured by the coefficient of variation (CV) of keypress for f 3-s and g 7-s trials; *P < 0.05 via a t test. Keypress CV correlated with cognitive function as measured by MOCA for h 3-s and i 7-s intervals. *P < 0.05 via Spearman’s rho.
