Table 2 Effects of predictors on cognitive status and motor symptoms through mediators when total WMH was used as a variable.

	BGdPVS			WMdPVS			Total WMH			Cognitive status			UPDRSIII
	β	SE	P	β	SE	P	β	SE	P	β	SE	P	β	SE	P
Hypertension	0.138	0.148	0.045	0.270	0.158	<0.001	0.033	0.153	0.640	−0.026	0.083	0.754	−0.126	1.435	0.097
Diabetes mellitus	−0.071	0.194	0.313	−0.140	0.206	0.069	0.029	0.193	0.674	−0.030	0.104	0.711	0.014	1.808	0.852
Dyslipidemia	−0.070	0.148	0.318	−0.191	0.157	0.013	0.013	0.148	0.847	−0.066	0.080	0.415	−0.100	1.391	0.179
OH	−0.097	0.190	0.170	−0.025	0.202	0.744	−0.073	0.187	0.289	0.020	0.102	0.806	0.120	1.762	0.109
SH	0.167	0.266	0.016	0.083	0.283	0.276	0.036	0.266	0.599	0.069	0.145	0.396	−0.047	2.501	0.529
RBD	0.047	0.160	0.514	0.079	0.170	0.316	−0.003	0.157	0.971	0.111	0.085	0.173	0.032	1.474	0.675
APOE ε4 carrier	0.103	0.183	0.136	−0.052	0.195	0.491	0.00	0.181	0.916	−0.023	0.098	0.776	−0.088	1.697	0.225
BGdPVS							0.440	0.079	<0.001	0.044	0.047	0.664	0.247	0.810	0.007
WMdPVS							−0.031	0.074	0.663	−0.020	0.040	0.812	−0.105	0.695	0.168
Total WMH										0.188	0.044	0.047	−0.046	0.753	0.593

Age, sex, years of education, disease duration, levodopa-equivalent dose, CCSIT score, and the presence of depression were used as covariates.
Abbreviations: β standardized beta coefficient, BG basal ganglia, dPVS dilated perivascular spaces, OH orthostatic hypotension, RBD REM sleep behavior disorder, SE standard error, SH supine hypertension, UPDRS III Unified Parkinson’s Disease Rating Scale III, WM white matter, WMH white matter hyperintensities.

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