Table 5 Prodromal PD Probability and Markers in siblings and DeNoPa cohorts.

	PROPAG-AGEING Siblings’ cohort				DeNoPa cohort	Comparisons with DeNoPa
	Total Sibs	Italian Sibs	Spanish Sibs	German Sibs	CTRs	CTRs vs German Sibs
	n = 300	n = 92	n = 96	n = 112	n = 107	IRR (CI)/β_coef. (CI)	Adj. p
Prodromal PD calculation
Prodromal PD probability (%)	0.75 (0.32–2.19)	0.54 (0.27–1.27)	0.80 (0.28–2.32)	1.07 (0.43–2.69)	–	–	–
Log₁₀(probability)	−0.04 ± 0.66	−0.20 ± 0.62	−0.06 ± 0.62	0.10 ± 0.70	–	–	–
Prodromal PD probability without fam. his. (%)	0.30 (0.13–0.91)	0.22 (0.11–0.57)	0.32 (0.11–0.94)	0.43 (0.17–1.09)	0.21 (0.12–0.45)	0.64 (0.51–0.82)	<0.001
Log₁₀(probability)	−0.40 ± 0.86	−0.49 ± 1.16	−0.45 ± 0.64	−0.28 ± 0.73	−0.58 ± 0.63	−0.22 (−0.41–−0.03)	0.025
Prodromal PD positive	1 (0.33%)	0 (0.0%)	0 (0.0%)	1 (0.9%)	0 (0.0%)	–	–
Prodromal PD markers	n = 340	n = 100	n = 120	n = 120	n = 109	OR (CI)	p
# of markers	0 (0–1)	0 (0–1)	0 (0–1)	0 (0–1)	0 (0–1)	0.75 (0.39–1.43)	0.388
≥2 markers	42 (12.3%)	8 (8%)	14 (11.7%)	20 (16.7%)	11 (10.1%)	0.53 (0.18–1.55)	0.247

Continuous, not normally distributed variables and ordinal variables are expressed in median (1st–3rd quartile), continuous, normally distributed variables are expressed in mean ± standard deviation, discrete in number (%). Adjustments have been made for age, sex, education, smoking, and coffee intake. Statistically significant coefficients and p-values are reported in bold.
Group acronyms are the same as explained in Table 1; Adj. p p-adjusted for covariates, IRR incidence rate ratio, CI 95% confidence interval, β_coef. coefficient of regression from linear regression, Prodromal PD probability without fam. his. prodromal PD probability computed without considering the history of PD in first-degree relatives, Log₁₀(probability) base 10 logarithm of prodromal PD probability.

Quick links

Search