Fig. 8: C16 in combination with Ang-1 treatment rescued the TH neurons. | npj Parkinson's Disease

Fig. 8: C16 in combination with Ang-1 treatment rescued the TH neurons.

From: Adjusting vascular permeability, leukocyte infiltration, and microglial cell activation to rescue dopaminergic neurons in rodent models of Parkinson’s disease

Fig. 8

a–t The DA neurons were stained using anti-TH (red) in both the nigra substance and striatum of PD rats (induced by 6-OHDA) and PD mice (induced by MPTP). Treatment with C16 (c, h, m, r), Ang-1 (d, i, n, s), and especially the combination of C16 and Ang-1 (e, j, o, t) reduced DA neuron loss in PD models (b, g, l, q). Panel a, f, k, p show DA neurons in normal controls. Scale bar = 100 µm. u, v Stereological analysis of DA neurons in the corpus striatum (u) and SN (v). a p < 0.05 versus the normal control group; b p < 0.05 versus the vehicle group; c p < 0.05 versus the C16-treated group; d p < 0.05 versus the Ang-1-treated group. DA, dopamine; TH, tyrosine hydroxylase; GABA, gamma-aminobutyric acid; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 6-OHDA, 6-hydroxydopamine; C16, peptide (KAFDITYVRLKF) that can selectively bind integrin ανβ3; Ang-1 angiopoietin-1; PD, Parkinson’s disease.

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