Table 4 Baseline predictors of delirium in parkinsonism.

From: First delirium episode in Parkinson’s disease and parkinsonism: incidence, predictors, and outcomes

Baseline predictor

All patients N = 287

PD patients with genetic data N = 115

Hazard ratio (95% CI)

P-value

Hazard ratio (95% CI)

P-value

Atypical parkinsonism vs PDa

2.83 (1.60–5.03)

<0.001

  

Age (10-year increase)

 In PD

2.29 (1.74–3.02)

<0.001

2.35 (1.64–3.36)

<0.001

 In atypical parkinsonism

1.27 (0.84–1.91)

0.26

  

Sex

1.16 (0.82–1.66)

0.42

1.43 (0.80–2.53)

0.22

DepCat

1.10 (1.00–1.23)

0.06

1.17 (0.98–1.39)

0.08

Charlson score

1.07 (0.94–1.22)

0.30

1.15 (0.92–1.44)

0.23

UPDRS part 3 (10-point increase)

1.04 (0.87–1.24)

0.68

1.34 (1.04–1.72)

0.02

MMSE (1-point increase)

0.94 (0.89–0.99)

0.04

1.00 (0.85–1.18)

0.98

GBA variant carrier

  

0.82 (0.30–2.20)

0.69

MAPT H1/H1

  

2.08 (1.08–4.00)

0.03

APOE ε4 carrier

  

2.16 (1.15–4.08)

0.02

  1. Mulitvariable Cox regression.
  2. DepCat deprivation score (higher DepCat score implies worse socioeconomic status), MMSE mini-mental state examination, UPDRS Unified Parkinson’s Disease Rating Scale, APOE Apolipoprotein E, GBA glucocerebrosidase, MAPT microtubule-associated protein tau.
  3. aAge re-parameterised so that this hazard ratio represents the increased hazards in atypical parkinsonism vs PD at age = 70.
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