Table 6 Effect of delirium on dementia and death.

From: First delirium episode in Parkinson’s disease and parkinsonism: incidence, predictors, and outcomes

Variable

Dementia

N = 239 (PD = 189, atypical parkinsonism = 50)a

Death

N = 289 (PD = 190, atypical parkinsonism = 100)

Hazard ratio (95% CI)

P-value

Hazard ratio (95% CI)

P-value

Period after delirium versus before delirium

 All patients

6.93 (4.18–11.49)

<0.001

  

 In PDb

  

3.76 (2.65–5.35)

<0.001

 In atypical parkinsonismb

  

1.59 (1.04–242)

0.03

Atypical parkinsonism vs PD

1.45 (0.77–2.75)

0.25

3.64 (2.40–5.52)

<0.001

Age at baseline (10-year increase)

1.66 (1.20–2.31)

0.002

1.69 (1.39–2.05)

<0.001

Sex

1.19 (0.71–1.98)

0.51

1.90 (1.44–2.52)

<0.001

DepCat

1.05 (0.89–1.23)

0.58

1.09 (1.00–1.18)

0.05

Baseline Charlson score

1.09 (0.91–1.31)

0.35

1.15 (1.06–1.25)

0.001

Baseline UPDRS part 3 (10-point increase)

1.12 (0.87–1.44)

0.39

1.26 (1.11–1.44)

0.001

Baseline MMSE

0.95 (0.87–1.04)

0.25

0.98 (0.94–1.02)

0.34

  1. Mulitvariable Cox regression with time-varying covariate.
  2. a50 patients with atypical parkinsonism were excluded because they developed dementia before entry into the study.
  3. bHazard ratios for the association between death and period before versus after delirium is presented separately for PD and atypical parkinsonism because a significant interaction between period and diagnosis was included in the model.
  4. DepCat deprivation score, MMSE mini-mental state examination, UPDRS Unified Parkinson’s Disease Rating Scale.
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