Fig. 2: Hierarchical clustering analysis of L2PD patients, iPD patients, and controls with heatmap density color representation of differentially expressed genes (DEGs) across different comparisons.
From: Transcriptome analysis in LRRK2 and idiopathic Parkinson’s disease at different glucose levels
a Discovery cohort at 25 mM glucose. b Discovery cohort at 5 mM glucose. c Validation cohort at 25 mM glucose. d Validation cohort at 5 mM glucose. Heatmaps of DEGs (P-value<0.05 and fold change FC ≥ |2|) were performed using default settings at the Clustvis software. e Venn diagram representation showing DEG overlap between PD vs. controls in the four different comparisons, where “A” corresponds to discovery 25 mM glucose, “B” discovery 5 mM glucose, “C” Validation 25 mM glucose, and “D” validation 5 mM glucose. Clustvis: https://biit.cs.ut.ee/clustvis/.
