Table 1 Biological enrichment analysis in all PD vs. controls.
From: Transcriptome analysis in LRRK2 and idiopathic Parkinson’s disease at different glucose levels
Discovery PD at 25 mM glucose | Discovery PD at 5 mM glucose | ||||
|---|---|---|---|---|---|
Biological process | P-value | Adj P-value | Biological process | P-value | Adj P-value |
Cell adhesion | 9.85E−31 | 2.84E−27 | Signal transduction | 1.26E−19 | 2.82E−16 |
Homophilic cell adhesion via plasma membrane adhesion | 8.42E−17 | 1.22E−13 | G protein-coupled receptor signaling pathway | 4.51E−17 | 5.06E−14 |
Nervous system development | 2.91E−16 | 2.80E−13 | Multicellular organism development | 2.20E−15 | 1.64E−12 |
Extracellular matrix organization | 1.19E−15 | 8.55E−13 | Cell adhesion | 2.64E−14 | 1.48E−11 |
Multicellular organism development | 1.65E−15 | 9.54E−13 | Positive regulation of ERK1 and ERK2 cascade | 1.43E−10 | 6.40E−08 |
Cell component | P-value | Adj P-value | Cell component | P-value | Adj P-value |
Membrane | 1.67E−70 | 7.83E−68 | Integral component of membrane | 4.31E−54 | 1.61E−51 |
Integral component of membrane | 8.47E−69 | 1.99E−66 | Membrane | 6.59E−50 | 1.24E−47 |
Plasma membrane | 3.46E−56 | 5.42E−54 | Plasma membrane | 4.86E−35 | 6.07E−33 |
Extracellular region | 5.86E−45 | 6.88E−43 | Extracellular region | 4.03E−34 | 3.78E−32 |
Cytoplasm | 6.59E−40 | 6.20E−38 | Cytoplasm | 1.14E−25 | 8.56E−24 |
Validation PD at 25 mM glucose | Validation PD at 5 mM glucose | ||||
|---|---|---|---|---|---|
Biological process | P-value | Adj P-value | Biological process | P-value | Adj P-value |
Cell adhesion | 7.86E−09 | 9.62E−06 | Synapse assembly | 6.56E−08 | 7.57E−05 |
Synapse assembly | 2.32E−08 | 1.42E−05 | Cell adhesion | 1.94E-06 | 0.0011 |
Ion transmembrane transport | 1.31E−07 | 5.34E−05 | Adult behavior | 3.75E-05 | 0.0054 |
Multicellular organism development | 4.02E−07 | 0.0001 | G protein-coupled receptor signaling pathway | 4.62E-05 | 0.0059 |
Immune system process | 5.58E−07 | 0.0001 | Signal transduction | 3.63E-05 | 0.0059 |
Cell component | P-value | Adj P-value | Cell component | P-value | Adj P-value |
Membrane | 7.71E−29 | 1.80E−26 | Plasma membrane | 2.11E−23 | 5.12E−21 |
Integral component of membrane | 2.39E−26 | 2.78E−24 | Membrane | 6.00E−21 | 7.26E−19 |
Plasma membrane | 5.07E−26 | 3.94E−24 | Integral component of membrane | 7.91E−18 | 4.78E−16 |
Extracellular region | 2.45E−21 | 1.43E−19 | Extracellular region | 6.12E−18 | 4.94E−16 |
Extracellular space | 1.81E−15 | 8.46E−14 | Extracellular space | 2.70E−14 | 1.31E−12 |
