Table 2 Most contributing lipid species of the most contributing classes to distinction between SNCA+/PD+ and SNCA−/PD−.

From: Lipid level alteration in human and cellular models of alpha synuclein mutations

Rank

Species

Species direction

Class

Class direction

95% CI and p value

1

PC.38.5

Positive

PC

Positive

(−0.203, −0.268), p = 0.0478

2

PC.36.3

Positive

PC

Positive

(−0.961, −0.128), p = 0.0116

3

Cer.d18.1.16.0

Negative

Cer

Positive

(−0.282, 0.008), p = 0.06345

4

TG.54.5.18.1

Negative

TG

Positive

(−0.706, 0.101), p = 0.1379

5

PC.36.4

Positive

PC

Positive

(−1.980, −0.186), p = 0.0190

6

TG.54.6.18.1

Positive

TG

Positive

(−0.307, 0.064), p = 0.1945

7

PC.38.3

Positive

PC

Positive

(−0.632, −0.032), p = 0.0309

8

PC.38.4

Negative

PC

Positive

(−1.364, 0.016), p = 0.0552

9

Cer.d18.1.22.0

Positive

Cer

Positive

(−0.330, 0.061), p = 0.1733

10

PC.38.2

Positive

PC

Positive

(−0.128, −0.001), p = 0.0478

11

TG.54.4.18.1

Positive

TG

Positive

(−1.568, −0.087), p = 0.0293

12

DG.38.1.18.0

Negative

DG

Positive

(0.0003, 0.011), p = 0.0360

13

TG.48.0.16.0

Positive

TG

Positive

(−0.427, 0.619), p = 0.7097

14

NAPE.p18.0.22.6.20.4

Negative

NAPE

Negative

(11.e−5,3 .4e−4), p = 0.0373

15

PC.36.1

Positive

PC

Positive

(−0.74, 0.00002), p = 0.050

16

DG.34.2.16.0

Positive

DG

Positive

(−0.206, 0.569), p = 0.2563

17

MhCer.d18.0.26.0

Negative

MhCer

Positive

(−7.5e−6, 6.1e−4), p = 0.0556

  1. Lipid acronyms: PC glycerophosphatidylcholine, Cer ceramide, TG triradylglycerol, DG diradylglycerol, NAPE N-acylphosphatidylethanolamine, MhCer monohexosylceramide. Most contributing lipid species of the most contributing classes (Table 1) as ranked by the RF in descending order of influence. Directions of impact are based on ridge regression, where positive means that the higher the concentration, the higher the probability of a subject to be classified as SNCA+/PD+. Bold or italic fonts indicate that a species is identified as contributing also when analyzed with all remaining species or by univariate regression, respectively. 95% CIs and p values are reported for the difference between the expected values of the two groups: SNCA+/PD+ and controls. The Bonferroni adjustment for multi comparisons is p < 0.0029.