Fig. 6: MGO-treatment alters respiratory electron transport chain and neurodegenerative-associated components in the midbrain of WT mice.
From: Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes
Proteomic differences between midbrain proteins from WT mice injected with vehicle or MGO. a Volcano plot for presenting statistically significant down- and upregulated hits. b KEEG pathways and Gene Ontology (GO) terms analysis is presented, depicting the number of down- and upregulated unique hits. Distribution of −log10 (Fisher exact test p value) is shown. c Heatmap of the uniquely altered proteins corresponding to the top 3 altered KEGG pathways. d Protein–protein interaction networks of the altered proteins, extracted from the STRING 11.0 database. Only the proteins that are interacting within a network are show. KEGG pathways or GO Biological processes are color coded.
