Fig. 8: MGO-treatment and aSyn overexpression similarly alters neurodegenerative- and oxidative phosphorylation-associated components in the midbrain.
From: Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes
Proteomic differences between midbrain proteins from WT or Thy1-aSyn mice injected with vehicle or MGO. a Venn diagram depicting midbrain proteome alterations between pairwise comparisons of MGO vs Vehicle-injected WT mice and Thy1-aSyn vs WT mice both injected with vehicle. From the identified 116 proteins, 72 are altered in the same direction (up- or downregulated). b KEEG pathways and Gene Ontology (GO) terms analysis is presented for the commonly altered proteins, depicting the number of down- and upregulated unique hits. Distribution of −log10 (Fisher exact test p value) is shown. c Heatmap of the commonly altered proteins corresponding to the top 3 altered KEGG pathways is presented per each pairwise comparison (aSyn—vehicle-Thy1-aSyn vs vehicle-WT; MGO—MGO-WT vs Veh-MGO). d Protein–protein interaction networks of the commonly altered proteins, extracted from the STRING 11.0 database. Only the proteins that are interacting within a network are show. KEGG pathways or GO Biological processes are color coded.
