Fig. 9: Glycation mainly impacts neurodegenerative- and dopaminergic synapse-associated pathways in the midbrain of MGO-injected Thy1-aSyn mice.
From: Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes
Glycation profile of midbrain proteins from the different experimental groups. a Venn diagram depicting glycated proteins (621) in MGO-injected Thy1-aSyn mice. b KEEG pathways and Gene Ontology (GO) terms analysis is presented for the glycated proteins in MGO-injected Thy1-aSyn mice. Distribution of −log10 (Fisher exact test p value) is shown. c Protein–protein interaction networks of the glycated proteins in MGO-injected Thy1-aSyn mice, extracted from the STRING 11.0 database. Only the proteins that are interacting within a network are show. KEGG pathways or GO Biological processes are color coded.
