Table 4 Effects of genetic risk scores and CSF biomarkers on longitudinal cognitive changes in PD patients.

		Visuospatial		Memory		Semantic fluency		Frontal/executive
	Predictors	β (SE)	P	β (SE)	P	β (SE)	P	β (SE)	P
Model 1	GRS-AD	−0.46 (0.14)	0.001^*	−0.20 (0.16)	0.210	−0.12 (0.74)	0.877	−0.25 (0.59)	0.679
	GRS-PD	0.12 (0.12)	0.344	0.10 (0.15)	0.516	2.14 (0.70)	0.002^*	0.79 (0.55)	0.150
	GRS-AD*GRS-PD	0.57 (0.17)	0.001^*
	time	−0.05 (0.02)	0.033	−0.03 (0.03)	0.284	−0.26 (0.11)	0.018	−0.60 (0.11)	<0.001^*
	GRS-AD*time	−0.07 (0.03)	0.037	−0.03 (0.04)	0.532	−0.25 (0.15)	0.111	−0.37 (0.15)	0.015
	GRS-PD*time	0.03 (0.03)	0.376	0.05 (0.04)	0.214	0.07 (0.14)	0.611	0.43 (0.14)	0.002^*
Model 2	GRS-AD	−0.50 (0.15)	0.001^*	−0.20 (0.18)	0.268	0.04 (0.84)	0.965	−0.20 (0.65)	0.755
	GRS-PD	0.11 (0.13)	0.417	0.24 (0.16)	0.132	2.47 (0.76)	0.001^*	0.96 (0.58)	0.100
	GRS-AD*GRS-PD	0.52 (0.18)	0.004
	time	−0.0004 (0.07)	0.996	0.23 (0.09)	0.009	0.54 (0.32)	0.098	0.23 (0.32)	0.476
	GRS-AD*time	−0.05 (0.04)	0.155	0.04 (0.05)	0.383	−0.09 (0.16)	0.592	−0.15 (0.16)	0.357
	GRS-PD*time	0.03 (0.03)	0.287	0.05 (0.04)	0.257	−0.009 (0.146)	0.948	0.47 (0.15)	0.001^*
	Baseline p-tau/Aβ₄₂	−0.004 (0.01)	0.694	0.003 (0.01)	0.787	−0.07 (0.06)	0.245	−0.02 (0.05)	0.612
	Baseline αSyn	−0.05 (0.14)	0.743	0.09 (0.18)	0.609	0.24 (0.84)	0.776	1.14 (0.64)	0.074
	Baseline p-tau/Aβ₄₂*time	−0.005 (0.003)	0.082	−0.02 (0.003)	<0.001^*	−0.05 (0.01)	<0.001^*	−0.07 (0.01)	<0.001^*
	Baseline αSyn*time	0.01 (0.04)	0.700	0.02 (0.04)	0.599	0.04 (0.16)	0.799	0.18 (0.16)	0.274

AD Alzheimer’s disease, GRS Genetic risk score, PD Parkinson’s disease, p-tau/Aβ₄₂ Phosphorylated tau/42-residue amyloid-beta.
Data are presented as the results of linear mixed models for each cognitive score, using age, sex, education, and the first four principal components as covariates. Predictors included GRS-AD, GRS-PD, GRS-AD*time, and GRS-PD*time for model 1. Baseline CSF p-tau/Aβ₄₂, αSyn, p-tau/Aβ₄₂*time, and αSyn*time were included as predictors in model 2.
Significant P values after false discovery rate correction for multiple statistical tests are indicated in bold.

Search