Fig. 2: Neurotransmitters modulate tremor activity in Parkinson’s disease (PD) via influencing cerebellar output.
From: A review on pathology, mechanism, and therapy for cerebellum and tremor in Parkinson’s disease
Various neurotransmitters including dopamine (DA), serotonin (5HT), and noradrenaline (NA), affect the cerebellar cortex (CER-COR), which modulate the output activity of dentate nuclei (DN). DN project to ventral intermediate nucleus of the thalamus (VIM) and modulate tremor activity. Orange arrows indicate projections between CER-COR, DN, and VIM. The Blue arrows indicate cerebellar output to other brain regions. Black arrows indicate the effect of neurotransmitters.
