Fig. 3: A reduction in the number of neurons with synaptic activity is observed in neurons derived from a sPD patient.

A No significant change was observed in the excitability measured by the total evoked potentials in the neurons derived from the sPD patient compared to controls. B Representative example of evoked action potentials in a control neuron. C Representative example of evoked action potentials in a neuron derived from a sPD patient. D No significant changes were observed in the sodium currents. E No significant changes were observed in the slow potassium currents. F No significant changes were observed in the fast potassium currents. G Example recording of synaptic currents in a neuron derived from a healthy control (the lower plot presents a zoom in on the segment denoted in the black dashed lines in the upper graph). H Example recording of synaptic currents in a neuron derived from a patient with sPD (the lower plot presents a zoom in on the segment denoted in the black dashed lines in the upper graph). I No significant change was observed in the mean amplitude of the synaptic currents in the sPD neurons. J No significant change was observed in the mean rate of the synaptic currents in the sPD neurons. K A significant reduction in the number of neurons that had synaptic activity was observed in sPD neurons compared to controls. L Signaling network analysis with the top enriched KEGG pathways for the sPD patient-derived neurons compared to the controls.