Fig. 4: Reduced synaptic activity in neurons derived from two sPD patients compared to control neurons.

A No significant change was observed in the excitability measured by the total evoked potentials in the neurons derived from the sPD patient compared to controls. B Representative example of evoked action potentials in a control neuron. C Representative example of evoked action potentials in a neuron derived from a sPD patient. D Sodium currents are increased in the sPD neurons compared to the controls. E The slow potassium currents are reduced in the sPD neurons compared to the control neurons. F The fast potassium currents are reduced in the sPD neurons compared to the control neurons. G A representative trace of synaptic currents in a control neuron (the lower plot presents a zoom-in on the segment denoted in the black dashed lines in the upper graph). H A representative trace of synaptic currents in an sPD neuron (the lower plot presents a zoom in on the segment denoted in the black dashed lines in the upper graph). I The mean amplitude of the synaptic currents was increased, but not significantly, in the sPD neurons. J The mean rate of synaptic currents was significantly reduced in the sPD neurons. K The cumulative distribution of the sPD neurons is slightly right-shifted, indicating large amplitudes of synaptic currents. L The capacitance of sPD neurons was significantly reduced in sPD neurons compared to control neurons.