Table 2 Cluster features comparison.

Variables included for clustering	Cluster A	Cluster B	Cluster C	p value^*
	Severe cluster	Intermediate	Mild cluster
	n = 43	n = 98	n = 65
Age of diagnosis (year)	69.6 ± 7.9	63.6 ± 7.4	59.4 ± 9.7	<0.001
PRS	0.7 (0.3–0.8)	0.7 (0.5–0.8)	0.7 (0.5–1.0)	0.100
Standardized Memory score	−1.8 (−2.6 to −0.9)	−1.3 (−2.0 to −0.7)	−0.1 (−0.6 to 0.3)	<0.001
Standardized Visuospatial score	−1.1 (−1.9 to 0.1)	−0.6 (−1.3 to −0.0)	−0.0 (−0.5 to 0.5)	<0.001
Standardized Attention score	−0.7 (−1.1 to −0.1)	−0.6 (−0.9 to 0.0)	0.3 (−0.4 to 0.9)	<0.001
Standardized Language score	−1.0 (−1.6 to −0.1)	−0.4 (−1.2 to 0.1)	0.3 (−0.0 to 0.8)	<0.001
Standardized Executive score	−0.7 (−1.5 to −0.2)	−0.4 (−0.9 to 0.2)	0.5 (0.1–1.0)	<0.001
MDS-UPDRS part I score	6 (3–8)	2.5 (1–4)	4 (2–7)	<0.001
MDS-UPDRS part II score	6 (4–9)	2 (1–4)	3 (1–6)	<0.001
MDS-UPDRS part III score	32 (26–37)	19.5 (15–24)	18 (14–20)	<0.001
PIGD score	3 (2–4)	1 (1–2)	1 (1–2)	<0.001
Tremor score	5 (3–8)	2 (0–4)	2 (0–3)	<0.001
Orthostatic SBP drop >10 mmhg (%)	15 (35%)	21 (21%)	7 (11%)	0.010
ESS Total Score	9 (5–12)	5 (2–8)	5 (3–7)	<0.001
HADS Anxiety score	2 (1–4)	1 (0–3)	2 (0–6)	0.055
HADS Depression score	4 (2–7)	2 (1–3)	2 (1–4)	<0.001
RBD1Q	0 (0–1)	0 (0-0)	0 (0–1)	0.520

All the variables were standardized before cluster analysis.
Categorical variables reported as frequency (%); continuous variables reported as mean ± standard deviation or median and first and third quartile (where appropriate)
^*Chi-square or Fisher exact test (where appropriate) for categorical variables, One-way ANOVA or Kruskal Wallis test for continuous variables (depends on normality assumption).
PRS polygenic risk score, MDS-UPDRS Movement Disorder Society-Unified Parkinson’s Disease Rating Scale, PIGD postural instability and gait disorder, SBP systolic blood pressure, ESS Epworth sleepiness scale, HADS Hospital Anxiety Depression Scale, NMSS non-motor symptom scale, RBD1Q rapid eye movement sleep behaviour disorder single-question screen.

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