Table 4 Allelic distributions of Asian related PD genes among the three PD clusters.

From: Biomarker characterization of clinical subtypes of Parkinson Disease

SNP

Effect allele

Cluster A

Cluster B

Cluster C

p value*

q value**

severe cluster

intermediate

mild cluster

n = 43

n = 98

n = 65

Park16 rs6679073

A

29 (67%)

72 (74%)

57 (89%)

0.015

0.065

SV2C rs246814

T

3 (7%)

12 (12%)

16 (25%)

0.026

0.065

SNCA rs6826785

C

36 (86%)

77 (86%)

51 (82%)

0.87

0.880

Lrrk2 rs141336855

T

1 (2%)

3 (3%)

3 (5%)

0.88

0.880

ITPKB rs16846351

G

6 (15%)

10 (11%)

5 (9%)

0.60

0.880

  1. *Fisher’s exact test was carried out to compare the Gene allelic distributions among different clusters.
  2. **False discovery rate (FDR) method was performed and q values were calculated to control for multiple testing and the threshold of q values was set as 0.1.
Back to article page