Fig. 1: Correlations of thalamic FC with pPDU. | npj Parkinson's Disease

Fig. 1: Correlations of thalamic FC with pPDU.

From: Functional connectivity of the cortico-subcortical sensorimotor loop is modulated by the severity of nigrostriatal dopaminergic denervation in Parkinson’s Disease

Fig. 1

Scatterplots for PD (red) and ET (blue) patients of the mean FC of the clusters (highlighted in the inserts on the right, the most affected side is at reader’s left) showing a significant inverse correlation of the thalamic FC (y axis) with pPDU (x axis) in PD patients. For the purposes of the graph, all clusters’ voxels were averaged as all the clusters from this contrast provided substantially overlapping patterns of correlation. FC of the thalamus on the MAS with bilateral rolandic cortices shows an inverse correlation with pPDU in PD patients, with no significant correlations in ET patients in the same regions. For demonstrative purposes, the FC maps at the level of the bilateral sensorimotor cortex of the PD patients at the extreme of the pPDU range are shown. A clear negative thalamic FC in the sensorimotor strips in the PD patient with the highest pPDU can be appreciated.

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