Fig. 2: GM atrophy and hypometabolism profiles in functional subregions of the striatum. | npj Parkinson's Disease

Fig. 2: GM atrophy and hypometabolism profiles in functional subregions of the striatum.

From: Involvement of striatal motoric subregions in familial frontotemporal dementia with parkinsonism harboring the C9orf72 repeat expansions

Fig. 2

a The striatal parcellations based on intrinsic functional connectivity to the cerebral cortex. Colors indicate functional subdivisions into the limbic, executive, sensorimotor, rostral-motor, caudal-motor, parietal, occipital, and temporal subdivisions. b Blue color corresponds to patterns of gray matter loss and hypometabolism in the FTDP patients compared to controls. Results are shown after correction for multiple comparisons using FDR p < 0.05. VBM analysis indicated significantly greater atrophy in the rostral-motor and caudal-motor regions of our FTDP patient (III-4) compared to the healthy controls. Similarly, voxel-wise examinations revealed hypometabolism in the rostral-motor and caudal-motor subregions compared to healthy controls, taking age and sex as covariates. In the other patient (III-6), significant GMV loss was also observed in the rostral-motor and caudal-motor subregions. However, no significant hypometabolism was observed in the rostral-motor and caudal-motor subregion.

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