Fig. 3: Alzheimer co-pathology in LBD.
From: A postmortem study suggests a revision of the dual-hit hypothesis of Parkinson’s disease
a Alzheimer (AD) co-pathology is common in the aged population. b Cases with early-stage amygdala-predominant LBD have more frequent AD co-pathology than expected for the age group, and the frequency of AD co-pathology increases further at late-stage disease. c Cases with early-stage brainstem/PNS-predominant LBD have AD co-pathology at the background level expected for the age group (same as in the black panel in a). However, cases with late-stage brainstem/PNS-predominant LBD display AD co-pathology almost as frequently as late-stage amygdala-predominant cases. This suggests that Lewy pathology promotes concomitant AD pathology, and this applies particularly to the brainstem/PNS-predominant group. [Note that the frequency estimates in the figure should be viewed as coarse approximations].
