Fig. 1: Statistical analysis results of the diffusion tensor image analysis along the perivascular space (DTI-ALPS) indexes.
a Comparison of DTI-ALPS indexes between PD and HCs. b Receiver operating characteristic (ROC) curves for diagnosing PDa and PDb using a single biomarker. c ROC curves for diagnosing PDa and PDb using the composite score. d Correlations between DTI-ALPS indexes and clinical characteristics in PD. The red and blue colors indicate positive and negative correlations, respectively. e Negative correlation between right-hemispheric DTI-ALPS index (DTI-ALPSr) and UPDRS III subscore in PD. f Negative correlation between DTI-ALPSr and UPDRS total score in PD. g Negative correlation between left-hemispheric DTI-ALPS index (DTI-ALPSl) and disease duration in PD. h Negative correlation between DTI-ALPSl and LEDD in PD. The error bars represent the standard deviation. *indicates p value < 0.05, **indicates p value < 0.01. PD Parkinson’s disease, PDa PD patients whose H&Y stage was lower than 2, PDb PD patients whose H&Y stage was higher than 2, HC healthy control, UPDRS unified Parkinson’s disease rating scale, H&Y stage Hoehn & Yahr stage, LEDD levodopa equivalent daily dose, HAM-D Hamilton depression rating scale, HAM-A Hamilton anxiety rating scale, MMSE mini-mental state examination, pcc Pearson correlation coefficient, scc Spearman correlation coefficient.
