Fig. 1: Workflow of the study and differential miRNA expression in DaT-negative L2NMC, DaT-positive L2NMC, L2PD patients, and iPD patients by genome-wide miRNA analysis in the discovery phase.
From: Differential serum microRNAs in premotor LRRK2 G2019S carriers from Parkinson’s disease
a Workflow of the study and number of participating subjects. b Volcano plot of differential miRNA expression between DaT-negative L2NMC and controls, c DaT-positive L2NMC and controls, d L2PD and controls, and e iPD and controls. Candidate differentially expressed miRNAs were defined as miRNAs with a fold-change above |1.5| and a p value below 0.05 under a two-tailed Student’s t test. Only names of the top-10 miRNAs are shown. Up-regulated and down-regulated DEmiR are respectively depicted in red and blue. DaT DaT-SPECT imaging, L2NMC LRRK2 non-manifesting carriers, L2PD LRRK2-associated PD patients, iPD idiopathic PD patients.
