Fig. 1: Study workflow and histopathological findings.
From: Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei
a Study worflow: brain sections of multiple sites, with particular regard to the brainstem, were sampled from 24 COVID-19 patients and 18 age- and sex-matched controls who died due to pneumonia and/or respiratory failure. b Left, coronal brain section of Subject #11 revealing extensive hemorrhagic injury in the territory of the middle cerebral artery. Right, sampling procedure of the brainstem through axial sections passing perpendicularly to the floor of the fourth ventricle. c Haematoxylin and eosin photomicrographs of the Dorsal Motor Nucleus of the Vagus in the medulla oblongata displaying various degrees of hypoxic/ischemic damage in COVID-19 subjects (upper row) and controls (lower row). d Platelet microthrombi at the level of the pons and cerebral cortex, CD61 immunohistochemistry.
