Fig. 6: COVID-19 microgliosis and associated microglial nodules.
From: Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei
a Low-magnification perspective of the medulla oblongata in COVID-19, displaying a ventral-to-dorsal increasing gradient of microglial densities (TMEM119, red; Beta-III Tubulin, green). b, c Double label TMEM119 (microglial marker, red) and Beta-III Tubulin (neuronal marker, green) immunofluorescent staining at the level of the medulla oblongata. Insets display neuronophagia at the level of the dorsal motor nucleus of the vagus in two COVID-19 subjects. d–h TMEM119+, CD68+ and HLA-DR+ microglial nodules in the olfactory bulb, medulla oblongata and midbrain of COVID-19 subjects.
