Fig. 7: Perivascular macrophages express anti-inflammatory marker CD206, while microglia display immunoreactivity for pro-inflammatory cytokines IL-1β, IL-4, TNF-α but not IL-4.
From: Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei
a Microglia and microglial nodules do not display CD206 immunoreactivity. b–d Perivascular monocytes/macrophage-like cells display CD206 immunoreactivity in both COVID-19 and control subjects. e, f Microglia and perivascular cells do not display immunoreactivity for CD86, in either COVID-19 or control subjects. g, h Welch corrected t-test reveals statistically significant differences between COVID-19 and control CD206+ cell densities in both medulla and midbrain. i–p Microglial cells are immunoreactive to pro-inflammatory cytokines IL-1β, IL-4, TNF-α but not IL-4.
