Fig. 1: Parallel assessment of neuropathology, GCase activity, and lipid levels in idiopathic and genetic PD. | npj Parkinson's Disease

Fig. 1: Parallel assessment of neuropathology, GCase activity, and lipid levels in idiopathic and genetic PD.

From: Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s disease

Fig. 1

a Study design. Post-mortem brain tissue was taken from four groups (LRRK2-PD/PDD, GBA-PD/PDD/DLB, idiopathic PD/PDD/DLB and matched controls. Four regions of brain were microdissected, leaving parallel sections for histology, lipid analysis or GCase activity analysis. Samples used for lipid or GCase activity analysis had white matter carefully resected away. b Ages of subjects at death. c Post-mortem interval of tissues. d Percentages of total group represented by each sex. Male (M) are blue-green and female (F) are orange. Bars represent mean ± S.E.M. with individual values plotted. One-way ANOVA; Tukey’s multiple comparison test. *p < 0.05, **p < 0.01.

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